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Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 311-320 doi: 10.1631/FITEE.1400425

Abstract: In some networks nodes belong to predefined groups (e.g., authors belong to institutions).former normalizes at the level of groups, the latter normalizes at the level of nodes. (2) Treating undirectednetworks as equivalent to symmetric directed networks, we expand the definition of gefura measures tothe directed case. (3) It is shown how Brandes’ algorithm for betweenness centrality can be adjusted

Keywords： Networks subdivided in groups     Partitions     Gefura measures     Q-measures     Brokerage role     Directed andundirected networks     Brandes’     algorithm    

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Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 519-525 doi: 10.1007/s11783-011-0326-2

Abstract: Application of directed evolution technology may be one of the most effective ways for improving thehydrolysis mechanism by cellulase, advances in cellulases (endoglucanase and -glucosidase) improvement by directedcharacteristics (for instance, thermal stability, pH adaptability and enzyme activity), limitations of directedevolution for cellulases, and the outlook for directed evolution for cellulase.

Keywords： biohydrogen     bioethanol     cellulase     cellulose     directed evolution    

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Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 10,   Pages 838-847 doi: 10.1631/FITEE.1500069

Abstract: Each agent is assumed to be governed by a second-order consensus control law corresponding to a directedThe first is concerned with directed trees, which represent the class of topology with minimum informationThe second is concerned with a more general graph that can be reduced to a directed tree by contracting

Keywords： Multi-agent systems     Controllability     Directed tree    

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Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 699-708 doi: 10.1007/s11705-021-2093-3

Abstract: In this work, an ionic strength directed self-assembly procedure is described for the preparation of

Keywords： layer-by-layer self-assembly     single bilayer     nanofiltration membrane     desalination    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 157-160 doi: 10.1007/s11684-007-0029-z

Abstract: This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directedIn short, ATP-TCA directed chemotherapy shows better results for terminal stages of PLC in that you can
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Site-directed mutagenesis of long QT syndrome KCNQ1 gene

LI Wei, WANG Bin, XU Qiumei, KE Qinmei, YANG Junguo, DU Rong, TIAN Li, WANG Qing

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 100-104 doi: 10.1007/s11684-008-0018-x

Abstract: To construct a polymerase chain reaction (PCR) site-directed mutagenesis of the long QT syndrome KCNQ1

Keywords： restriction     digestion     syndrome     sequence     site-directed mutagenesis    

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oocyst directed assembly of gold nanoparticles and graphene oxide

Sona Jain, Zhicheng Huang, Brent R. Dixon, Syed Sattar, Juewen Liu

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 608-615 doi: 10.1007/s11705-019-1813-4

Abstract: Understanding the interactions between inorganic nanomaterials and biological species is an important topic for surface and environmental chemistry. In this work, we systematically studied the oocysts of as a model protozoan parasite and its interaction with gold nanoparticles (AuNPs) and graphene oxide (GO). The as-prepared citrate-capped AuNPs adsorb strongly on the oocysts leading to a vivid color change. The adsorption of the AuNPs was confirmed by transmission electron microscopy. Heat treatment fully inhibited the color change, indicating a large change of surface chemistry of the oocysts that can be probed by the AuNPs. Adding proteases such as trypsin and proteinase K partially inhibited the color change. DNA-capped AuNPs, on the other hand, could not be adsorbed by the oocysts. GO was found to wrap around the oocysts forming a conformal shell reflecting the shape of the oocysts. Both citrate-capped AuNPs and GO compromised the membrane integrity of the oocysts as indicated by the propidium iodide staining experiment, and they may be potentially used for inactivating the oocysts. This is the first example of using nanomaterials to probe the surface of the oocysts, and it suggests the possibility of using such organisms to template the assembly of nanomaterials.

Keywords： nanomaterials     toxicology     water     biosensors    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract: therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- )Thus, the MRD-directed immunotherapy was effective for patients with high-risk MDS who were MRD-positive

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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Novel interpretable mechanism of neural networks based on network decoupling method

Frontiers of Engineering Management 2021, Volume 8, Issue 4,   Pages 572-581 doi: 10.1007/s42524-021-0169-x

Abstract: The lack of interpretability of the neural network algorithm has become the bottleneck of its wide application. We propose a general mathematical framework, which couples the complex structure of the system with the nonlinear activation function to explore the decoupled dimension reduction method of high-dimensional system and reveal the calculation mechanism of the neural network. We apply our framework to some network models and a real system of the whole neuron map of Caenorhabditis elegans. Result shows that a simple linear mapping relationship exists between network structure and network behavior in the neural network with high-dimensional and nonlinear characteristics. Our simulation and theoretical results fully demonstrate this interesting phenomenon. Our new interpretation mechanism provides not only the potential mathematical calculation principle of neural network but also an effective way to accurately match and predict human brain or animal activities, which can further expand and enrich the interpretable mechanism of artificial neural network in the future.

Keywords： neural networks     interpretability     dynamical behavior     network decouple    

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Development of a dual temperature control system for isoprene biosynthesis in

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1079-1089 doi: 10.1007/s11705-021-2088-0

Abstract: A cold-sensitive mutant, Gal4ep19, was created by directed evolution of Gal4p based on an internallyThis study reports the creation of the first cold-sensitive variants of Gal4p by directed evolution and

Keywords： transcriptional activator     directed evolution     dynamic control     heat-shock     isoprene    

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Capacity analysis for cognitive heterogeneous networks with ideal/non-ideal sensing

Tao HUANG, Ying-lei TENG, Meng-ting LIU, Jiang LIU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 1,   Pages 1-11 doi: 10.1631/FITEE.1400129

Abstract: to irregular deployment of small base stations (SBSs), the interference in cognitive heterogeneous networks

Keywords： Cognitive heterogeneous networks     Markov chain     Stochastic geometry     Homogeneous Poisson point process (    

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Study and Application of Steady Flow and Unsteady Flow Mathematical Model for Canal Networks

Zhang Mingliang,Shen Yongming

Strategic Study of CAE 2007, Volume 9, Issue 8,   Pages 92-96

Abstract: and canal networks is developed and the key issues on the model are expatiated particularly in this This model is applied to simulating the tree-type irrigation canal networks and complex loopedcanal networks.and river networks.and canal networks.

Keywords： Preissmann implicit scheme     canal networks and river networks     discharge distribution     water quality    

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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 213-221 doi: 10.1007/s11705-015-1541-3

Abstract: Biological application of conjugates derived from oligonucleotides and quinone methides have previously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic acids. To enhance the rates of these processes, a new quinone methide precursor with an electron donating substituent has been prepared. Additionally, this substituent has been placed to the nascent -methylene group of the quinone methide for maximum effect. A conjugate made from this precursor and a 5'-aminohexyloligonucleotide accelerates formation of its reversible self-adduct and alkylation of its complementary DNA as predicted from prior model studies.

Keywords： quione methide     DNA alkylation     reversible covalent reaction     bioconjugation     target-directed modification    

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Title Author Date Type Operation

Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Journal Article

Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Journal Article

Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Journal Article

Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Journal Article

Site-directed mutagenesis of long QT syndrome KCNQ1 gene

LI Wei, WANG Bin, XU Qiumei, KE Qinmei, YANG Junguo, DU Rong, TIAN Li, WANG Qing

Journal Article

oocyst directed assembly of gold nanoparticles and graphene oxide

Sona Jain, Zhicheng Huang, Brent R. Dixon, Syed Sattar, Juewen Liu

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Novel interpretable mechanism of neural networks based on network decoupling method

Journal Article

Development of a dual temperature control system for isoprene biosynthesis in

Journal Article

Capacity analysis for cognitive heterogeneous networks with ideal/non-ideal sensing

Tao HUANG, Ying-lei TENG, Meng-ting LIU, Jiang LIU

Journal Article

Study and Application of Steady Flow and Unsteady Flow Mathematical Model for Canal Networks

Zhang Mingliang,Shen Yongming

Journal Article

DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Journal Article